Suspected sulfasalazine‐induced acute hepatic necrosis in a dog after one year of continuous treatment

An 18-month-old male entire golden retriever presented with inappetence and a 12-hour history of episodic vomiting. The dog had been receiving sulfasalazine 15 mg/kg twice daily for one year the treatment lymphoplasmacytic colitis, which was well controlled prior to presentation. no other drug or toxin exposure. Investigations initially revealed raised liver enzymes, increased during hospitalisation along development neutropenia thrombocytopenia. During hospitalisation, acute hepatic necrosis diagnosed histologically, recovered completely supportive discontinuation sulfasalazine. believed be associated toxic-metabolite dependent idiosyncrasy due long-term use Unlike cases previously reported, this developed these clinical signs after rather than immediately therapy initiation. This may raise awareness about possible late-onset reactions when using long courses sulfonamides.